Burke et al. show that exosomes derived from MDSC contained hetero-oligomer S100A8/A9, which could induce a RAGE dependent autocrine loop that promotes the accumulation of MDSCs within the tumor niche [52], and in fine triggered hematopoietic stem cells and progenitor cells death, contributing to ineffective hematopoiesis. The gene discussed is IGKV1D-22; the disease is neoplasm.