RUNX2 and acute myeloid leukemia: Antileukemic mechanisms induced by BET inhibitors are currently not well understood but recently, a study showed that in AML cells, S100A8 and S100A9 expression could be downregulated by JQ1, a benzodiazepine molecule and a specific BET inhibitor in some AML cell lines (i.e., OCI-AML3) [76].