These results were supported by Laouedj et al., on 437 AML (excluding acute promyelocytic leukemia (APL)) that showed an overexpression of the S100A8 and A9 transcripts in the AML M4 and M5 compared to the poorly differentiated AML (AML M0 and M1) [32]. The gene discussed is IGKV1D-22; the disease is acute myeloid leukemia.