Moreover, the particular prevalence of clonal hematopoiesis of indeterminate potential (CHIP) in elder patients, who suffer from chronic inflammatory diseases very frequently, raise the hypothesis that inflammation-associated secretion of S100A8 and S100A9 could be a factor that participates in the evolution of CHIP toward frank acute myeloid leukemia, which frequency significantly increases with age. The gene discussed is S100A8; the disease is acute myeloid leukemia.