SAMHD1 and cancer: Due to its role in DSBR, it is conceivable that mutations in the SAMHD1 gene, as well as silencing hypermethylation of the SAMHD1 promoter, might play a role in tumorigenesis of various forms of cancer such as colon cancer, chronic lymphocytic leukemia, and lung adenocarcinoma [30,34,35,36].