Given IGFBP-3 overexpression suppresses the angiogenic and metastatic activities of NSCLC cells [22,23,24,28], we assessed whether IGFBP-3 regulates the proliferative, migratory, and invasive activities of HNSCC and NSCLC cells and investigated how IGFBP-3 exhibits such activities. The gene discussed is IGFBP3; the disease is head and neck squamous cell carcinoma.