We next examined whether EPA treatment affected p-STAT3 and HPS expressions by SUIT-2 cells and found that EPA significantly reduced the p-STAT3/STAT3 expression ratio and HPS protein levels at concentrations of 60 and 80 μM in SUIT-2 cells at 48 h (Figure 5C,D), indicating that EPA might reduce KRAS/p-STAT3-mediated HPS expression and cell growth in pancreatic cancer cells. Here, FGL1 is linked to pancreatic neoplasm.