To further explore the effects of HPS on pancreatic cancer cells, we extracted lipid contents and analyzed the lipidomic composition between the controls (Void and Scramble) and HPS knockdown (shHPS#21 and shHPS#90) SUIT-2 cells by LS/MS/MS with a principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA). Here, FGL1 is linked to pancreatic neoplasm.