A high expression of phosphorylated STAT3 was shown in liver metastatic pancreatic (LMP) cell lines derived from LSL-KrasG12D/+/Pdx1Cre/+ (KC) mice, compared to pancreatic intraepithelial neoplasia (PanIN) or primary PDAC cells [32], suggesting that STAT3 activation is an important factor that promotes metastatic and advanced stages of pancreatic cancer. This evidence concerns the gene STAT3 and familial pancreatic carcinoma.