Since MAP1LC3B coded protein LC3B has two forms including LC3B-I and LC3B-II and the levels of LC3B-I and LC3B-II are dynamically changed during a functional autophagy process in ERBB2-negative (MAD-MB-231) and ERBB2-positive (SKBR3 and MCF7) cells (Figure 1, Figure 2 and Figure 3), we chose to further study the roles of ATG12 in ERBB2-regulated autophagy and treatment resistance in breast cancer cells. The gene discussed is ATG12; the disease is breast cancer.