IFNG and neoplasm: In another study, Th1-derived IFNγ was shown to increase macrophage-mediated anti-tumor cytotoxic activity by inducing the expression of proteases, granzyme A/B, and NK cell-related genes (e.g., NKG2D) and by promoting CXCL9 and CXCL10 secretion by macrophages [75].