PCSK9 and coronary artery disorder: Interestingly, in a recent analysis of 539 subjects with coronary artery disease (60.3 ± 8.6 years, 256 males), statin treatment did not significantly affect PCSK9 plasma levels (222 ± 1 and 202 ± 9 ng/mL), and the significant correlation between LDL-C and PCSK9 was lost in the statin-treated subjects, compared with non-statin users [25].