CD8A and hepatocellular carcinoma: Surprisingly, and in contrast to HCV-specific CD8+ T cells in cHCV patients, antigen-experienced MAGE-A-specific CD8+ T cells do not show a terminally exhausted phenotype (Eomeshi, PD-1hi, TCF-1lo, CD127lo) in therapy-naïve HCC patients [102], potentially reflecting different quantities and qualities of antigen recognition.