Based on the expression of the inhibitory receptor PD-1 and the IL-7 receptor α-chain CD127, Wieland et al. could identify CD127+ PD-1+ memory-like subsets expressing the transcription factor TCF-1 and CD127- PD-1high Eomeshigh terminally differentiated subsets of exhausted HCV-specific CD8+ T cells in cHCV infection. Here, CD8A is linked to infection.