The nucleotide variation in the promotor region of the IL-1B gene at loci -31 and -511 and the VNTR polymorphism of its receptor antagonist gene can explain individual differences in the dynamics of IHD and differences in the progression of atherosclerosis of the coronary arteries undergoing invasive diagnostics because of ACS, especially for patients with a first ACS before 60. This evidence concerns the gene IL1B and atherosclerosis.