OBSCN and Arrhythmogenic right ventricular dysplasia: In addition, several human obscurin gene variants have been linked to the development of hypertrophic cardiomyopathy, dilated cardiomyopathy, left ventricular noncompaction or arrhythmogenic right ventricular cardiomyopathy [28,34], all of which underscore the importance of obscurin for proper cardiac function.