In addition, several human obscurin gene variants have been linked to the development of hypertrophic cardiomyopathy, dilated cardiomyopathy, left ventricular noncompaction or arrhythmogenic right ventricular cardiomyopathy [28,34], all of which underscore the importance of obscurin for proper cardiac function. The gene discussed is OBSCN; the disease is left ventricular noncompaction.