INS and type 2 diabetes mellitus: In our cohort of overweight and obese patients with uncontrolled T2D by either MET alone or in selective combination with conventional insulin secretagogues (predominantly a sulfonylurea), the addition of DU 1.5 mg/once weekly significantly improved glycemic control, with a mean 6-month HbA1c reduction of −0.85%, which remained stable for up to 18 months.