Additional candidate biomarkers for HCC in the blood have been suggested, i.e., proprotein convertase subtilisin/kexin type 9 (PCSK9) [54,55], glypican 3 (GPC3), squamous cell carcinoma antigen (SCCA), cytokeratine-19, osteopontin (OPN), Golgi protein-73 (GP73), alpha-L-fucosidase (AFU) [56], heat shock 70 kD protein (HSP-70) [57], annexin A2, midkine (MDK), aldo-keto reductase family 1 member B10 (AKR1B10) [58], and HCC-responsive miRNAs and cell-free DNA (for a more detailed review, see [59]). Here, SPP1 is linked to hepatocellular carcinoma.