BCL2L1 and Parkinson disease: Finally, with regard to PD, it is worth be noted that Bcl-xL was reported to interact with the PTEN-induced putative kinase 1(PINK-1 kinase), which may contribute to PINK-1-dependent protection against cell death [11], and to prevent the mitochondrial localization of Parkin, inhibiting in this way mitochondrial protein ubiquitination and subsequent mitophagy [12,37].