PRDM1 and otitis media with effusion: A study of transcription factors involved in antibody production in MEF obtained during surgery for OME found that the expression of BLIMP-1 and IgA was significantly lower in the OME-prone than in the non-prone OME group, suggesting that the reduction in antibody production in response to reduced BLIMP-1 expression would reduce immunity against pathogens and contribute to the recurrence and chronicity of OME [50].