In the studies by Masharani et al. [52] in people with type 2 diabetes, a positive effect was noted in the lipid profile (the PD group had statistically significant declines in TC, HDL-C, and LDL-C), carbohydrate metabolism (the PD group had greater benefits on glucose control and significant improvement in insulin sensitivity), and, interestingly, body composition (the average weight changes were similar in both groups without caloric restriction), while the pressure remained unchanged (the mean arterial pressure did not significantly change in any of the two groups) [52]. Here, INS is linked to type 2 diabetes mellitus.