POLR2A and triple-A syndrome: POLR2A gene, which is shown in the current study as downregulated in LEAD vs. AAA (Table 2) and negatively correlated with creatinine level (Table 3), was previously found as involved in congenital obstructive nephropathy [88] and encoded protein was strongly functionally linked to dysregulated proteins in animal models of salt-induced kidney damage [89].