In addition, ABCB1 substrate drug vinblastine (VBL)- or trans-flupentixol (tFPT)-induced membrane ruffling is an early indicator of cellular motility and metastatic potential in ABCB1 overexpressing MCF7/AdrR and ABCB1 transfectant MCF7/BC-19 breast cancer cells (Figure 5B) [122]. This evidence concerns the gene ABCB1 and breast cancer.