A series of imaging studies in vivo using 99mTc-sestamibi (technetium-99m sestamibi a.k.a. Cardiolite), an ABCB1 substrate, further confirmed that ABCB1-mediated drug extrusion is enhanced in some patients with breast carcinomas [41,42,43]. This evidence concerns the gene ABCB1 and breast carcinoma.