The failure of generating ABCB-/CD44s+ transfectants and the decrease in the cell migration of ABCB1-silenced CD44s-overexpressing cells probably mirrors the fact that ABCB1 expression might be coregulated with CD44s, and CD44s plays its role in the cell migration of breast cancer on the premise of a functional ABCB1 expression [111]. The gene discussed is ABCB1; the disease is breast cancer.