High-density qRT-PC studies investigating different times of the disease progression revealed overexpression of inflammatory genes Il1rn [IL-1Ra], Ccl8 [CCL8/MCP-2], Tnfsf11 [Tnfsf11/RANKL], and Osm [OSM]) at the preclinical stage in scrapie strain 22L-infected mice). The gene discussed is TNFSF11; the disease is scrapie.