SLC7A11 and ovarian carcinoma: In the report of Wang et al. [32] cooperation between ovarian cancer cells and fibroblasts upon cisplatin treatment has been ascribed: 1) to xCT presence in the plasma membrane of fibroblasts which allows them to import as much cystine as possible from the extracellular space, and 2) to both cysteine and GSH provided from cystine metabolism in the fibroblasts (Figure 3A).