This seems counterintuitive on its own as ERK1/2 activation has been shown to stimulate Nrf2 nuclear localization and induce antioxidant defenses [63], however, since tumor growth was clearly reduced after PT treatment, it is entirely possible that PT inhibits AKT in MM and thereby inhibits Nrf2 activation as evidenced through enhanced ROS generation. Here, AKT1 is linked to Miyoshi myopathy.