Aberrant signaling in the sonic hedgehog (SHH) pathway caused by mutations in PTCH1, PTCH2, and SUFU genes, located at 9q22.32, 1p34.1, and 10q24.32, respectively, with PTCH1 being the most common, increases the risk of meningioma development [65]. The gene discussed is PTCH2; the disease is meningioma.