CD4 and systemic lupus erythematosus: This restoration of the microbiota could be responsible of the immunomodulatory activity of this probiotic that reduced the percentage of B cells, as well as the levels of T reg (CD4+/FoxP3+) cells, Th17 (CD4+/IL-17a+) cells, and Th1 (CD4+/IFN-γ+) cells, which were increased in the mesenteric lymph nodes from SLE mice (Table 4).