The synbiotic also ameliorated the glucidic profile by reducing the plasma levels of glucose and insulin, thus improving homeostasis model assessment of insulin resistance (HOMA-IR) index, which is used to determine the severity of insulin resistance and prevented the hypertriglyceridemia and hyperleptinemia that occurred in rats fed the high fructose diet [112] (Table 4). This evidence concerns the gene INS and Insulin resistance.