The results presented here, especially those concerning the absence of a correlation between the isoform ratio and the invasiveness of tumour (Figure 1C,D,G,H), suggest that the differential expression of ZNF518B isoforms is not responsible for the effects of the gene on the dissemination of CRC cells [9], although the isoform ratio correlates with relapsing. This evidence concerns the gene ZNF518B and neoplasm.