MiR-122 is a negative regulator of A Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) and serum response factor (SRF), which are both involved in EMT (SFR is also implicated in tumor angiogenesis) and insulin growth factor 1 receptor (IGF1R), which activates the downstream RAS/RAF/ERK pathway, induces proliferation and promotes metastasis [89]. Here, SRF is linked to neoplasm.