ZEB1 and neoplasm: Furthermore, while miR-200c was found to be downregulated in trastuzumab-resistant GC cells, thereby proving to act as a tumor suppressor miRNA, its overexpression restored trastuzumab sensitivity and blocked the EMT by targeting Zinc finger E-box-binding homeobox 1 (ZEB1) and 2 (ZEB2), which are downstream molecules of TGF-β.