OPA1 and eye disorder: Of these, 44 had mutations in 11 genes responsible for high myopia eye disease, including COL2A1, COL11A1, PRPH2, FBN1, GNAT1, OPA1, PAX2, GUCY2D, TSPAN12, CACNA1F and RPGR. The initial clinical records of the 71 patients with mutations did not show any diseases other than high myopia.