In fact, a decrease in mean methylation of the relative CpG islands in both HMCLs was associated with increased mRNA levels only for COX10, MAP1LC3, MTIF3, and RAB32 genes, while CpGs hypomethylation in both MM cell lines was related to higher expression levels of COX10 mRNA in pathological samples. This evidence concerns the gene MTIF3 and Miyoshi myopathy.