In the mammalian small intestine, electroneutral NaCl absorption is the predominant mechanism of absorption of the electrolytes Na and Cl, which occurs through the functional coupling of brush border membrane (BBM) exchangers mediating Na:H exchange (NHE3/SLC9A3) and Cl:HCO3 exchange (DRA, Downregulated in Adenoma/SLC26A3 and PAT1, Putative Anion Transporter-1/SLC26A6) [13,14,15,16]. This evidence concerns the gene SLC9A3 and adenoma.