The spectrum of factors involved in PRAT induced local tumor progression comprises overexpression of UCP-1 associated with perirenal adipocytes, underexpression of HOXC8 and HOXC9, and a possible added PRAT “browning” in clear cell renal carcinoma, promotion of tumor progression by adipokines and pro-inflammatory cytokines released by dysfunctional perirenal fat, cachexia due to brown adipocytes activation, and dedifferentiation of mature adipocytes at the invasive tumor front. This evidence concerns the gene HOXC8 and neoplasm.