PNPLA3 and Insulin resistance: In best subset regression models that included PNPLA3 SNPs, HCV status, HIV status, alcohol use determined by AUDIT, age, sex at birth, insulin resistance, race/ethnicity, BMI, and diabetes (fasting blood glucose > 126), models that included PNPLA3 SNPs, HIV, ethnicity, diabetes, sex at birth, and BMI yielded the best overall model.