Given that MMPs can promote the activation of TNF-α and TNF-α signaling promotes the deactivation of AMPK, we suggest that the convergence of increased MMP proteolytic activity, increased TNF-α levels, and reduced AMPK activity could have a synergic and negative impact on the metabolic pathways regulated by AMPK in COVID-19 patients (Figure 1B). The gene discussed is PRKAA1; the disease is COVID-19.