PTGS1 and osteoporosis: Our results showed that (1) women with a homozygous genotype in the MYLK rs12163585 major alleles had an increased risk of osteoporosis following ovariectomy than those with minor alleles, and (2) women who had the minor PTGS1 rs1213265 allele and were not ovariectomized carried a higher risk of osteoporosis than those with homozygous genotype of the major alleles and undergoing ovariectomy.