Moreover, overexpression of c-MYC—a highly expressed MYC-family gene in the MYCN non-amplified high-risk NBs—in the PSNS of transgenic fish could also induce NB tumorigenesis [51], thus implicating the key oncogenic role of MYC family genes in NB pathogenesis. The gene discussed is MYC; the disease is Nijmegen breakage syndrome.