MYCN and neuroblastoma: Further evidence of the reliability of the zebrafish model has been provided by research showing that overexpression of MYCN in the zebrafish PSNS under control of the dβh promoter induces adrenal sympathetic neuroblast hyperplasia [33], which is consistent with the observation of hyperplastic lesions in the adrenal glands of LSL-MYCN;Dbh-iCre mice [105] or in sympathetic ganglia of TH-MYCN mice [22,106], the other two popular NB mouse models with MYCN overexpression.