However, besides the mentioned benefits by combined SRT and ADT in subgroups of PC patients (for example with persisting PSA after RP, PSA of ≥0.7 at start of SRT, or patients with <0.7 ng/mL and additional risk factors like Gleason ≥8 or R0 margins in RP) we have also to realize the side effects and sometimes significant adverse events of ADT [19,38]. Here, KLK3 is linked to pachyonychia congenita.