M2-like cells release cytokines IL-4, IL-10, IL-13, and growth factors TGF-β, vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), which exhibit pro-tumorigenic properties: stimulate cell proliferation, tumor encapsulation, and vasculogenesis and promote drug resistance [6,7]. This evidence concerns the gene EGF and neoplasm.