As macrophage polarization and cytokine production rely on the cell transcriptional machinery, we aim to discuss the major TFs involved in cytokine network regulation-NF-κB, STAT-family, IRF-family, and p53,-in the context of the tumor microenvironment and chemo- and radiotherapy (Figure 1 and Figure 2, Table 3). This evidence concerns the gene TP53 and neoplasm.