M1-like macrophages show a high capacity for antigen presentation and increased production of nitric oxide (NO), reactive oxygen species (ROS), and proinflammatory cytokines (interleukin (IL) IL-1β, IL-6, tumor necrosis factor alpha (TNF-α), and others), playing a dual role in the tumor microenvironment [13,14]. The gene discussed is TNF; the disease is neoplasm.