When summarizing the existing data it can be observed that various treatments tend to impact M2-associated TFs, such as nuclear factor erythroid 2-related factor 2 (Nrf2), peroxisome proliferator-activated receptor gamma (PPAR-γ), cAMP response element-binding protein (CREB), and some others, which may be due to the immunosuppressive properties of the tumor microenvironment. Here, NFE2L2 is linked to neoplasm.