This has also been explored in the plasma samples of TGCT patients, with Kawakami and collaborators detecting demethylated XIST in 64% plasma samples from TGCT patients (71% and 55% seminoma and non-seminoma, respectively), with no detection in the plasma of 24 males with other urological malignancies (bladder and renal cancer). The gene discussed is XIST; the disease is seminoma.