For example, GLP-1 participates in neuroprotection, the signaling of appetite suppression by the brain, the postponement of gastric emptying, the decrease of gastric acid output and gastric motility in the stomach, the increasing of glucose uptake in muscle, the inhibition of hepatic IR, the alleviation of hepatic steatosis in the liver, positive inotropic and chronotropic effects, and the increase of reperfusion after cardiac ischemia [36,41]. The gene discussed is GLP1R; the disease is fatty liver disease.