MUC6 and Alzheimer disease: The variants within MUC6 were within a region with complex tandem repeats and further inspection, using long range PCR, cloning, Sanger sequencing and restriction digestion identified a highly polymorphic VNTR within MUC6. This group then explored the relationship between AD neuropathology in autopsied individuals and reported that individuals with longer VNTR regions had significantly more pTau burden.