As previously observed in IP NAX014-treated mice [11], IG NAX014 administration was able to induce cell senescence in tumor masses, as revealed by increased in situ expression of tumor suppressor p16. The in vitro β-galactosidase assay on HER-2 overexpressing SK-BR-3 cells demonstrated the involvement of cellular senescent-like pathways in the NAX014-mediated antitumor effects. This evidence concerns the gene ERBB2 and neoplasm.