B7-H4 expression is positively correlated with cancer development in patients with gastric cancer [77], glioma [78], squamous cell esophageal carcinoma [79], renal cell carcinoma [80], pancreatic cancer [81], cholangiocarcinoma [18], ovarian cancer [82], and lung cancer [83]. Here, VTCN1 is linked to familial pancreatic carcinoma.