In glioma, miR-539 upregulation, which can suppress B7-H3 expression, can repress cancer development by targeting caspase recruitment domain-containing, membrane-associated, guanylate kinase protein-1 (CARMA1), sperm-associated antigen 5 (SPAG5), and the gene encoding matrix metalloproteinase 8 (MMP8) [34]. Here, SPAG5 is linked to central nervous system cancer.