Moreover, phosphorylation of ND-42 (the fly ortholog of NdufA10), a complex I subunit that is necessary for proper complex I function, is Pink1-dependent [95], directly linking Pink1 to complex I. These data were confirmed and further validated in patient-derived fibroblasts carrying PINK1 mutations [95], suggesting that the mitochondrial ETC serves as a therapeutic target in PINK1-related PD. The gene discussed is PINK1; the disease is Parkinson disease.