LRRK2 is a kinase that affects endocytosis via the LRRK2-dependent phosphorylation of Endophilin A [140,141], an endocytotic protein [142] and Synaptojanin [143] that plays an essential role in synaptic vesicle recycling [144] further supporting vesicle trafficking to be a common function in PD-related proteins. This evidence concerns the gene LRRK2 and Parkinson disease.