TRPV1 and rosacea: Among the TRPV subfamilies, TRPV1 participates in cutaneous neurogenic inflammation and pain as a nociceptive cationic channel, mainly for Ca2+, and can be activated by various rosacea trigger factors, including osmotic or pH changes, high temperature exposure (above 43 °C), and ultraviolet B (UVB) light exposure [3,4,5].