INS and obesity due to melanocortin 4 receptor deficiency: In another study, Lo et al. identified a lncRNA ~20kb upstream the LEP gene, which they named lnc-Leptin, whose expression was elevated in obesity, decreased by fasting, and induced by insulin, but which displayed a positive correlation with leptin expression in a spectrum of pathophysiological conditions, suggesting that this lncRNA acts probably as an enhancer-lncRNA [103].