CASCADES is expressed in IDH wild-type GBM and significantly enriched in GSCs Knockdown of CASCADES in GSCs results in a decrease in the stemness markers, Nestin and Sox2, an increase in the neuronal marker, Tuj1, and a corresponding decrease in Cyclin B1 and Olig2, consistent with differentiation of GSCs towards a neuronal lineage in a cell- and cancer-specific manner. The gene discussed is LINC01994; the disease is glioblastoma.