The CRNDE promotes malignant progression of glioma by acting as a ceRNA sponge for miR-384 and inhibiting the activation of miR-384 target piwi-like RNA-mediated gene silencing 4 (PIWIL4) and its downstream protein signal transducer and activator of transcription 3 (STAT3) [158]. Here, PIWIL4 is linked to central nervous system cancer.