ABCA1 and Hyperglycemia: Additionally, hyperglycemia impairs renal cholesterol homeostasis by down-regulating cholesterol efflux transporters, adenosine triphosphate binding cassette (ABC) transporter A1 (ABCA1), ABC transporter G1 (ABCG1), and scavenger receptor class B type I, while increasing the cluster of differentiation 36, CD36, which, in turn, activates lipogenesis [33].