The CXCL4 capacity to condense DNA/RNA in nanocrystalline structures could facilitate anti-CXCL4 autoantibody generation in SSc, as particulate structures confer antigenicity to otherwise poorly immunogenic molecules [13,14], and in fact, we have demonstrated that CXCL4 acts as an autoantigen in a consistent proportion of SSc patients. Here, PF4 is linked to systemic sclerosis.