High levels of serum IgE (>1000 U/mL) and a positive hypersensitivity skin test or increased IgE antibody to Aspergillus are required criteria together with at least two additional supportive features: eosinophilia (>500 cells/μL), Aspergillus-specific IgG, and/or radiographic findings [32]. This evidence concerns the gene IGHE and Increased total eosinophil count.