Also, CXCL16 increases CXC motif chemokine ligand 8 (CXCL8)/IL-8 expression in prostate PC3 and C4-2B cancer cells [29] and in hepatocellular carcinoma SK-HEP-1 and HCCLM3 cells [32]. This evidence concerns the gene CXCL16 and hepatocellular carcinoma.