CXCR6 and cancer: Likewise, CXCR6 expression in gastric cancer HGC-27 cells [102] is positively associated with the proliferation of cancer cells, as well as CXCL16 expression in osteosarcoma U2OS and SaOS2 cells [89], and CXCR6 in osteosarcoma MG-63 cells [103].