Experiments on hepatocellular carcinoma SK-HEP-1 and HCCLM3 cells did show that the activation of CXCR6 causes a reduction in p38 MAPK activation and thus the activation of glycogen synthase kinase 3β (GSK3β), which leads to a reduction in the amount of β-catenin in the plasma membrane [32]. The gene discussed is CXCR6; the disease is hepatocellular carcinoma.