PPARGC1B and Parkinson disease: However, since in other tissues PGC-1β is able to drive genes involved in de novo lipogenesis, including SCD1 [141,142], and given that SCD1 expression has proved to be deleterious for PD, it would be intriguing to evaluate if PGC-1β retains this ability also in DA neurons and whether the activation of this pathway may have detrimental effects.