Although no direct interaction has been observed between PGC-1α and DJ-1, since DJ-1 can compensate for PINK1 loss, it will be intriguing to evaluate if PGC-1α functions can be rescued by DJ-1 expression in PD cells in terms of mitochondrial biogenesis and antioxidant response [90,176]. This evidence concerns the gene PPARGC1A and Parkinson disease.