In addition, the recent development of mds84, the bivalent binder occupying both T4 binding pockets simultaneously, has attracted attention because it has shown highly potent effects not only for tetramer stabilization but also for the prevention of TTR proteolysis [18]; the proteolysis-induced fragmentation of TTR was recently proposed as an important mechanism facilitating TTR amyloidosis [19,20]. This evidence concerns the gene TTR and amyloidosis.