IL2 and neoplasm: The cytokines were chosen, because they are important drivers of the tumor microenvironment toward either the Th1 (IL-2, IFN-γ, TNF-α, IL-12, IL-15 and CXCL-10) or the Th2 (CCL-2, CCL-4, CCL-22, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13 and TGF-β) profile [10].